The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. Limits of long-term selection against Neandertal introgression. Further palaeogenomic studies on Upper Palaeolithic individuals from the Balkans will be essential for understanding whether southeastern Europe represents the source of the Villabruna ancestry and a climatic refugium for human populations during the LGM. C. Posth and H.Y. Details of the grouping and ROH segments are provided in Data S3.B. Tina Huang: Data science, computer science, and career advice expert. The genomic similarity of the Oberkassel cluster to Arene Candide 16 in northwestern Italy might imply that Epigravettian-associated ancestry spread from the south to central Europe passing through the western side of the Alpine region. Adv. This free online conference is featuring panel discussions from OUR UNIVERSITY Our University . Proc. Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. b, Population diversity shown by PMR between individuals in different groups. Dismiss. Natl Acad. The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. I have been watching Tina's YouTube channel's videos since the past month and find her explanations / reviews very useful and actionable and being in Toronto myself I think it will be same contextually when I start applying for DSc jobs (and make the big switch from Healthcare that I am in currently). The ROH segments in hunter-gatherer genomes were identified using hapROH101. In each of the past 200 years they have only seen four new entrants into their top 200 list. These data cover a time span of around 30,000 years from the Upper Palaeolithic to the Late Neolithic (defined here by the presence of pottery rather than by farming subsistence economy if not indicated), derive from multiple prehistoric cultural contexts, and originate from 54 archaeological sites in 14 countries: 1 Aurignacian-associated individual from Belgium and 1 culturally unassigned individual from Romania (3533ka), 15 Gravettian-associated individuals from Spain, France, Belgium, Czechia and Italy (3126ka), 2 Solutrean-associated individuals from Spain and France (2321ka), 9 Magdalenian-associated individuals from France, Germany, and Poland (1815ka), 4 Epigravettian-associated individuals from Italy (1713ka), 2 Federmesser-associated individuals from Germany (14ka), and 81 Mesolithic to Neolithic foragers from across western Eurasia (115ka), together with 1 central Eurasian Neolithic individual from Tajikistan (8ka) (Fig. Photo by Sara Kurfe on Unsplash 1. Google Scholar. Int. Sign In Create Free Account. Modern humans have populated Europe for more than 45,000 years 1, 2. Mathieson, I. et al. Contrary to the proposal in Fu et al.4 but in agreement with Petr et al.17, we do not observe a substantial decrease of Neanderthal ancestry in most European hunter-gatherers through time (Supplementary Information, section6 and Supplementary Figs. "It is possible that the migration of early farmers into Europe triggered the retreat of hunter-gatherer populations to the northern edge of Europe. PubMed Rep. 10, 21931 (2020). Both of these ancestries carry a genetic component distantly related to the Goyet Q116-1 individual dated to 35ka, with the Iberian individual also showing an affinity to the Villabruna cluster4,14. Evol. Le palolithique suprieur en Italie. 1). Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. Other individuals from that period, such as Zlat k from Czechia and UstIshim from Russia, do not carry significantly more Neanderthal ancestry than other non-African groups1,7, indicating differential interactions between Neanderthals and early modern humans during their initial expansions across Eurasia. The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). The competition is based on a pretty strict data set thats been collected by the Stanford Computer Science department. Revise SQL essentials, improve your communication style and tackle the most challenging follow-up questions with ease. In sum, we describe the formation and interaction between the Oberkassel and Sidelkino clusters, the two main hunter-gatherer ancestries present in Europe from 14ka onwards. Check out Why is Burnout So Common in Tech? Ideally, we also want lots of data because this will give us more confidence in our results. ADS Planning and Learning in Partially Observable Systems via Filter Stability Noah Golowich (MIT); Ankur Moitra (Math & CSAIL, MIT); Dhruv Rohatgi (MIT) New Subset Selection Algorithms for Low Rank Approximation: Offline and Online David P. Woodruff, Taisuke Yasuda (Carnegie Mellon University) Good Quantum LDPC Codes with Linear Time Decoders Irit Dinur (Weizmann); Min-Hsiu Hsieh (Hon Hai Quantum . An early modern human from Romania with a recent Neanderthal ancestor. As the coverage for most ancient samples was not sufficient for diploid genotype calling, we counted the reads covering selected phenotypic SNPs on reference or alternative alleles and computed the group-based allele frequencies following a maximum likelihood approach described in Mathieson et al.37. With the statistics f4(Mbuti, Fournol 85; Vstonice, test) and f4(Mbuti, Vstonice; Fournol 85, test), we show that all Vstonice-cluster individuals are significantly closer (|Z|>3) to the Vstonice group (n=5) and the Fournol-cluster individuals are closer to Fournol 85, whereas the geographically intermediate Gravettian-associated Goyet group shows extra affinity to both clusters (Fig. received support from the Estonian Research Council grant PUT (PRG243). Data warehousing is a relatively new field that focuses on the use of large datasets for analytical purposes. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Expand search. This button displays the currently selected search type. Biol. Jobs People Learning Dismiss Dismiss. Overall, the literature suggests that Chinese Canadian students demonstrate high levels of achievement and that this academic success is associated with factors such as stronger feelings of ethnic identity, better English language skills in the family, Chinese . My name is Tina and I'm a data scientist and YouTuber. Antonio, M. L. et al. Google Scholar. Bioinformatics 38, 37683777 (2022). "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. USA 110, 22232227 (2013). I am attending the Future of Data and AI by Data Science Dojo on March 1st and 2nd, 2023. Both double-stranded and single-stranded libraries were further amplified with IS5/IS6 primers to reach a concentration of 200400ng/l as measured on a NanoDrop spectrophotometer (Thermo Fisher Scientific). Extended Data Fig. These authors contributed equally: Cosimo Posth, He Yu, Archaeo- and Palaeogenetics, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, Senckenberg Centre for Human Evolution and Palaeoenvironment at the University of Tbingen, Tbingen, Germany, Cosimo Posth,Dorothe G. Drucker,Herv Bocherens,Christoph Wiing,Nicholas J. Conard&Katerina Harvati, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, Cosimo Posth,He Yu,Ayshin Ghalichi,Hlne Rougier,Yilei Huang,Harald Ringbauer,Adam B. Rohrlach,Kathrin Ngele,Vanessa Villalba-Mouco,Rita Radzeviciute,Tiago Ferraz,Alexander Stoessel,Rezeda Tukhbatova,Wolfgang Haak&Johannes Krause, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China, Department of Anthropology, California State University Northridge, Northridge, CA, USA, Universit de Bordeaux, CNRS, MC, PACEA UMR 5199, Pessac, France, Isabelle Crevecoeur,Andr Morala,Stphane Madelaine,Priscilla Bayle,Bruno Maureille,Jean-Guillaume Bordes&Mona Le Luyer, School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia, Instituto Universitario de Investigacin en Ciencias Ambientales de Aragn, IUCA-Aragosaurus, Zaragoza, Spain, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany, Institute of Zoology and Evolutionary Research, University of Jena, Jena, Germany, Center of Excellence Archaeometry, Kazan Federal University, Kazan, Russia, Department of Biology, University of Florence, Florence, Italy, Martina Lari,Alessandra Modi&Stefania Vai, Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia, Tina Saupe,Christiana L. Scheib&Luca Pagani, St Johns College, University of Cambridge, Cambridge, UK, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy, Department of Biology, University of Padova, Padova, Italy, Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Bologna, Italy, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, UMR 8068 CNRS, TEMPSTechnologie et Ethnologie des Mondes Prhistoriques, Nanterre Cedex, France, Laurent Klaric,Olivier Bignon-Lau,Grgory Debout,Michel Orliac,Pierre Bodu,Bndicte Souffi&Frdrique Valentin, Muse National de Prhistoire, Les Eyzies de Tayac, France, UMR 5140 CNRS, Archologie des Socits Mditerranennes, Universit Paul-Valry, Montpellier, France, UMR 7194, Histoire Naturelle de lHomme Prhistorique (HNHP), Dpartement Homme et Environnement, Musum National dHistoire Naturelle, CNRS, UPVD, Paris, France, Association APRAGE (Approches pluridisciplinaires de recherche archologique du Grand-Est), Besanon, France, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK, Dipartimento di Scienze Fisiche, della Terra e dellAmbiente, U.R. Her YouTube channel is dedicated to data and computer science, including how to educate yourself in these topics. I hold a Bachelors degree at the University of Toronto where I studied pharmacology. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. In the meantime, to ensure continued support, we are displaying the site without styles The more information you have the more data you need to analyze and make your predictions. Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Genetics 203, 881891 (2016). We generated genome-wide sequencing data for 102 newly reported hunter-gatherers, and increased coverage for 14 previously published individuals4. Mittnik, A. et al. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. The hunter-gatherers were grouped based on their geographic origins and dates (Supplementary Information, section5). This study focuses on the people who lived between 35,000 and 5,000 years ago and that are, at least partially, the ancestors of the present-day population of Western Eurasia, including -- for the first time -- the genomes of people who lived during the Last Glacial Maximum (LGM), the coldest phase of the last Ice Age, around 25,000 years ago. Gonzlez-Fortes, G. et al. Tina Huang is a recent graduate of Stanford. We did not correct the calibrated dates for marine or freshwater reservoir effects but, when available, we report individual stable isotope values (15N/13C and C:N ratio) in Supplementary Data 1.A to evaluate the potential impact of such reservoir effects. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. Edit your profile. (black) or 3s.e.m. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. Product development is, by far, my favorite data science use case for two main reasons. This is also validated by f4-statistics of the form f4(Mbuti, Zlat k; test1, test2), which are consistent with zero for all other pre-LGM hunter-gatherers (Supplementary Data 2.C), indicating an equidistant relationship of Zlat k to the tested groups. View Tina Huang's profile on LinkedIn, the world's largest professional community. As inferred from the archaeological record35, the spread of the Magdalenian across Europe is linked to southwestern to northern and northeastern post-LGM population expansions and not to movements from southeastern refugia34. As previously hinted37, we find a large frequency variation in alleles related to skin and eye pigmentation among post-LGM hunter-gatherer groups. No need to do it alone our community of learners and instructors is there for you. Evol. By co-analysing previously published data with our newly reported genomes associated with the Magdalenian from La Marche (18ka) and Pincevent (15ka) in western and northern France, respectively, and Maszycka (1816ka) in southern Poland, we confirm that the Goyet Q116-1 ancestry survived in all studied Magdalenian-associated genomes besides in Gravettian and Solutrean-associated individuals from southwestern and western Europe (Fig. For the placement of individuals onto a Y-chromosomal phylogenetic tree (Extended Data Fig. An improved, lightweight and secure authentication scheme in context of fog-centric IoT communication is proposed in this paper to eradicate all the above mentioned security shortfalls of Wajid et al scheme. Branch labels show unique drift lengths; black dots refer to individuals with newly generated data and white dots refer topreviously published genomes;the position of each node does not imply the location where the split took place. It is not intended to provide medical or other professional advice. Google Scholar. Admixture events were dated using the ancestry covariance pattern-based DATES 753 program105, with a bin size of 0.1 cM for covariance calculation and the start of exponential fitting at d0.5cM. Paradis, E., Claude, J. is supported by a Ramn y Cajal fellowship (RYC-2017-22558). performed or supervised laboratory work. 9 posts. DNA analysis of an early modern human from Tianyuan Cave, China. Conversely, the ancestry found in pre-30ka eastern European individuals (Kostenki cluster and Sunghir group) contributed to Gravettian-associated individuals from central and southern Europe (Vstonice cluster), the latter without descendantsretrieved in post-LGM populations from those regions. You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. 21, 199 (2020). Hi friends! Commun. The labels in italic denote previously published individuals without new data generated in this study. This was confirmed with qpAdm, in which we could model all individuals from the Oberkassel cluster as a broadly constant mixture of approximately 75% Arene Candide 16 and 25% Goyet Q-2 (or 90% Arene Candide 16 and 10% Fournol 85) (Fig. Google Scholar. Jodie Sweetin. Curr. A negative and cave bear positive controls were included. Cosimo Posth, He Yu or Johannes Krause. Tina Huang Profile page. If youd like to learn more about data science, transitioning into computer science, and software engineering, you can also subscribe to my YouTube channel. We also genotyped a selection of previously published individuals with the same approach (Supplementary Data 1.G)2,4,30,74,75,76,77,78. Low latency, reasonably low communication overhead and ability to support real time applications are the reasons for . 2022 Weird Science Plus - All Rights Reserved. Well be back on Friday so, if youre not already, get subscribed to the Brandwatch Bulletin right away. 26 and Supplementary Data 2.H). One of the best-known and most liked personalities in the data community, Tina is a successful YouTuber and works with one of the FAANG companies. Moreover, the Oberkassel cluster carries both Villabruna ancestry and a contribution from GoyetQ2 ancestry (Supplementary Data 2.J). & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. All in the name of developing an amazing product! NEWSLETTER: https://tinahuang.substack.com/ It's about learning, coding, and generally how to get your sh*t together c: I've been a FAANG data scientist f. Tina Huang is a Data Scientist at a FAANG (Facebook, Amazon Apple, Netflix, Google) company. Sci. There is no biographical data to display. The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". Pseudo-haploid genotypes were called on the targeted SNPs by randomly sampling a single allele at each position, resulting in individuals with 6,600 to 1.07 million SNPs covered on the 1.24-million-SNP panel (Extended Data Table 1 and Supplementary Data 1.A). Google Scholar. Hajdinjak, M. et al. Also if you want to see some cat pics. Fu, Q. et al. Biol. Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. 12). CAS Graduate - February 2015 to September 2015. Bold letters refer to (a) mtDNA and (b) Ychr haplogroups, whose boxes are coloured according to the legend in Extended Data Fig. Jones, E. R. et al. & Nielsen, R. ANGSD: analysis of next generation sequencing data. Article A series of f4-symmetry statistics confirm that all the Epigravettian-associated individuals are cladal, and do not share excess affinity with any local (Paglicci 12) or non-local preceding ancestries (Goyet Q116-1, Kostenki 14, Malta 1 or Vstonice) (Supplementary Data 2.F). Shes currently at Microsoft. EY. Huang's parents immigrated to New York City where her two older brothers . They were different in many aspects, including their skin and eye colour," says He Yu. 4, 11 (2007). Ontario Institute for Cancer Research Toronto, ON. A 5700 year-old human genome and oral microbiome from chewed birch pitch. Save my name, email, and website in this browser for the next time I comment. This results in a tree with 57 newly reported and previously published ancient individuals while present-day sequences are collapsed in the major Y-chromosome haplogroups (the most basal lineages are not shown). 5 and Supplementary Information, section9). Since she graduated, shes been working at a company that develops software for the Windows operating system. Wonderful course so far Tina. & Zimmermann, A. Max Planck Institute for Evolutionary Anthropology. Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. 2022 Fab Business Solutions - All Rights Reserved. This means that you have to set up the database tables to represent the data (which can be done by using the right database design patterns) and then run some SQL queries to extract the data that you need. Genomic structure in Europeans dating back at least 36,200 years. We then removed samples with less than 0.04X coverage (calculated on the mappable, non-recombining region of the Y chromosome98) to avoid arbitrarily placing low-coverage samples at the root of major haplogroups. Interviewed Taiwanese designers and analyzed the interview data. Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. This Villabruna ancestry(hereafter, Villabruna cluster or ancestry) showed connections to ancient and present-day Near Eastern populations4,16, but the mode and tempo of its expansion into the Italian peninsula remain unexplored. Seguin-Orlando, A. et al. In the video above, she explains the two major components of big data: data warehousing and data science. Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. Powered by Symplectic part of Digital Science . I'm I've learned SQL before, but I need a refresher. Check out Bootcamps Yes or nah? Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. 7 Admixture dates between Oberkassel/Villabruna and ANE ancestries in the oldest individuals from the Sidelkino cluster. 27, 32023208.e9 (2017). We tested the affinity of Tutkaul 1 to worldwide ancient and modern populations relative to AG3. Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. An equimolar pool of all libraries was then prepared for shotgun sequencing on Illumina Hiseq4000 platform using 75bp single-end reads for screening. . and JavaScript. 2c). We looked at data on how many people had been dropped, the time when they were dropped, and the time they were found. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. Article use of cookies The mapped reads from the same individual and library set-up were merged and duplications were removed with DeDup. Here, we report genomic data from 4 individuals, including 3 approximately 13,000-year-old genomes from northeastern Italy (Pradis 1), northwestern Italy (Arene Candide 16) and Sicily (San Teodoro 2), as well as increased genome-wide coverage from Tagliente 215 dated to 17ka. The sex of each individual was determined by the ratio of sequencing coverages on sex chromosomes versus autosomes (Supplementary Data 1.C). Each bar represents one individual with the ROH grouped in four length categories (grouped by colour). Li, H. et al. Tina Huang is one of the top three students to show up to compete. PubMedGoogle Scholar. First, we show that individuals associated with the Gravettian culture across Europe were not a biologically homogeneous population. "Ice Age survivors." Lazaridis, I. et al. Tina Huang Data Scientist. Narasimhan, V. M. et al. In other cases, you may have to create a more complex database structure (such as SQLite). Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. Wyprodukowany w konwencji anime serial stanowi spin-off produkcji "Midzy nami, Misiami", ktrej reyserem wykonawczym . I'm a data scientist and youtuber. E.A. The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. She has been working for the data sciences industry since 2014. Feldman, M. et al. For contaminated libraries we used the PMD-filtered bam files as the input for genotyping. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. In practice, we use machine learning in different conjunctures. Our analyses demonstrate that the Fournol cluster is a better source for Magdalenian-associated genomes than Goyet Q116-1. Catalano, G. et al. - Developing a high . . She was not prepared for the complexity of a typical programming language. Sci. Her code challenge was titled Bias-Explained by Quantitative Data. Nature 524, 216219 (2015). I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. Evol. Publications. The genomic history of southeastern Europe. 412, 3743 (2016). Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. 5). 44, W58W63 (2016). The f3-statistics were calculated with qp3Pop 435 in ADMIXTOOLS 5.1 package103. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). Sci. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. Quat. However, using f4-statistics, we show that all Magdalenian-associated individuals, and not only El Mirn, carry Villabruna-related ancestry whencompared tothe Fournol cluster(Supplementary Data 2.H). We detect the highest amount of ROHs in Epigravettian-associated individuals from Sicily, who carry an extreme amount of more than 200cM of short ROHs (48cM). B. et al. The mitochondrial capture sequencing reads were cleaned by AdapterRemoval 2.2.0 to remove the adapters and reads with lengths below 30bp. and T. Saupe received support from the European Union through the European Regional Development Fund (project no. Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. K.N., V.V.-M., R.R., T. Ferraz, R.T., D.G.D., M.L., A. Modi, S. Vai, T. Saupe, C.L.S., G. Catalano, L. Pagani, D.C. and E.A. 9). Great content - Tina is all class and an excellent instructor. It involves lots of hypothesis testing and statistics which 365 Data Science also has a wonderful course on.
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